Taking detox pills for weight loss is often coupled with fasting or calorie restriction. With short-term fasting, limited calories may result in you feeling hungry, fatigued or irritable. It is very rare to experience severe side effects from a single meal replacement weight loss detox for a limited period of 15 to 30 days.
However, if you experience any severe side effects such as dehydration, cramping, bloating, nausea or vomiting you should immediately stop and consult a doctor.