3 Surprising Benefits of Glucosamine Beyond Bone Health
- A study found that people who used glucosamine + chondroitin at least four days per week for three or more years had a 45% lower risk of developing colorectal cancer than those who didn’t.
- Glucosamine stimulates the production of hyaluronic acid, which might help improve skin hydration, reduce wrinkles, and accelerate wound healing.
- The combination of glucosamine and chondroitin can help lower inflammation, especially in people with excess weight.
Glucosamine is a natural substance in the body. Your body uses glucosamine to make other chemicals that build tendons, ligaments, cartilage, and the fluid that lubricates the joints.
Glucosamine is a widely consumed dietary supplement. It is known for supporting joint health and easing arthritis symptoms. But did you know its benefits go far beyond your bones and joints?
Here are three lesser-known benefits of glucosamine beyond bone health.
May Support Gut Health
Studies have shown that glucosamine might help improve the diversity of the bacteria in the gut. In one study, researchers found that people who received glucosamine had higher levels of beneficial bacteria like Prevotellaceae genera, Alloprevotella, and Paraprevotella.
Glucosamine has also been found to be helpful in reducing stomach bloating and constipation. The action of glucosamine in regulating the gut microbiome might also help manage certain fat metabolism disorders caused by inflammation.
May Help Reduce Inflammation
Glucosamine also has anti-inflammatory properties. One study found that the combination of glucosamine and chondroitin can help lower inflammation, especially in people with excess weight.
In addition, the combined effects of glucosamine and chondroitin on reducing inflammation may help prevent colorectal cancer, as chronic inflammation is a known risk factor for its development. In one study, people who used glucosamine + chondroitin at least four days per week for three or more years had a 45% lower risk of developing colorectal cancer than those who didn’t. However, more studies are needed to confirm this benefit.
Might Boost Skin Health
Glucosamine has also been found to trigger the production of hyaluronic acid, a compound known for its hydrating properties.
Due to glucosamine’s effect on stimulating the production of hyaluronic acid, some researchers believe it might help improve skin hydration, reduce wrinkles, and accelerate wound healing.
In addition, glucosamine was shown to inhibit melanin production, which may help treat hyperpigmentation disorders.

Is Glucosamine Safe?
Glucosamine is generally safe. However, it can cause mild side effects, including bloating, diarrhea, and constipation. In addition, glucosamine has been found to increase blood sugar levels and heart disease in some people. Hence, it should be used with caution in people who have diabetes or are at risk of heart disease. If you have any of these conditions, talk to your healthcare provider before using glucosamine.
In addition, glucosamine is produced from the shells of shrimp, lobster, and crabs. If you have a shellfish allergy, please consult your healthcare provider before using glucosamine.
The Science of Joint Wellness Formula
Choosing the best glucosamine supplement means choosing a brand with the right quality, formulation, ingredients, and form. The ingredients in the joint wellness formula were carefully selected after a series of experiments to ensure they work synergistically.
GLUCOSAMINE
Glucosamine may slow down the destruction of the cartilage, a tissue that cushions joints and supports smooth movement. This can help reduce swelling and pain, especially in people with arthritis.
CHONDROITIN
Chondroitin is another important cartilage component. Like glucosamine, chondroitin may reduce pain and swelling and slow cartilage breakdown. Researchers have found that chondroitin and glucosamine work together to protect cartilage and slow joint damage.
BOSWELLIA
Boswellia is a natural compound used for centuries in traditional medicine for its anti-inflammatory and pain-relieving properties. Boswellia is safe and may effectively reduce pain and improve the quality of life in people with persistent knee pain.
QUERCETIN
Quercetin is a powerful antioxidant that helps fight oxidative stress. It may help protect against the development and progression of osteoarthritis.
BROMELAIN
Bromelain is an enzyme found in pineapples. It is rich in antioxidants and anti-inflammatory properties, which may help reduce swelling, pain, and inflammation associated with arthritis and sports injuries.

Conclusion
While glucosamine is one of the best supplements for supporting joint and cartilage health, its benefits go beyond just bones. It may help regulate gut health, support skin hydration, and reduce inflammation.
Whether you’re dealing with joint discomfort or simply looking to support your overall health naturally, glucosamine might just be worth adding to your daily routine.
Our glucosamine supplement, Joint Wellness Formula, might be a good place to start if you are looking for natural ways to support joint health and overall wellness.
Each ingredient in our best glucosamine supplement: glucosamine sulfate, chondroitin, and MSM, was thoughtfully chosen for its ability to support joint comfort. Together, they offer synergistic relief from joint pain and other benefits.
References
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